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Advances in High-Throughput, High-Capacity Nonwoven Membranes for Chromatography in Downstream Processing: A Review
  • +2
  • Cristiana Boi,
  • Joseph Lavoie,
  • Jinxin Fan,
  • Behnam Pourdeyhimi,
  • Ruben Carbonell
Cristiana Boi
NC State University

Corresponding Author:cristiana.boi@unibo.it

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Joseph Lavoie
NC State University
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Jinxin Fan
NC State University Department of Chemical and Biomolecular Engineering
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Behnam Pourdeyhimi
NC State University Department of Chemical and Biomolecular Engineering
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Ruben Carbonell
NC State University
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Abstract

Nonwoven membranes are highly engineered fibrous materials that can be manufactured on a large scale from a wide range of different polymers, and their surfaces can be modified using a large variety of different chemistries and ligands. The fiber diameters, surface areas, pore sizes, total porosities, and thicknesses of the nonwoven mats can be carefully controlled, providing many opportunities for creative approaches for the development of novel membranes with unique properties to meet the needs of the future of downstream processing. Fibrous membranes are already finding use in ultrafiltration, microfiltration, depth filtration, and, more recently, in membrane chromatography for product capture and impurity removal. This article summarizes the various methods of manufacturing nonwoven fabrics, and the many methods available for the modification of the fiber surfaces. It also reviews recent studies focused on the use of nonwoven fabric devices in membrane chromatography and provides some perspectives on the challenges that need to be overcome to increase binding capacities, decrease residence times, and reduce pressure drops so that eventually they can replace resin column chromatography in downstream process operations.
13 Feb 2023Submitted to Biotechnology and Bioengineering
14 Feb 2023Submission Checks Completed
14 Feb 2023Assigned to Editor
14 Feb 2023Review(s) Completed, Editorial Evaluation Pending
24 Feb 2023Reviewer(s) Assigned
23 Apr 2023Editorial Decision: Revise Minor
04 May 20231st Revision Received
04 May 2023Submission Checks Completed
04 May 2023Assigned to Editor
04 May 2023Review(s) Completed, Editorial Evaluation Pending
17 May 2023Editorial Decision: Accept