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DNA sensing in the pathological process of ischemic stroke
  • ShiWen Zhang,
  • ChaoRan Wu,
  • Hong Liao
ShiWen Zhang
China Pharmaceutical University
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ChaoRan Wu
China Pharmaceutical University
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Hong Liao
China Pharmaceutical University

Corresponding Author:hliao@cpu.edu.cn

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Abstract

The innate immune response plays an important role in the pathological process of ischemic stroke. Increasing evidence suggests that the inflammatory response triggered by the innate immune system hinders neurological and behavioral recovery after stroke. The perception of abnormal DNA and its downstream effects are an important part of the innate immune system. The abnormal DNA is the major inducing factor for innate immune response and is sensed by a series of DNA sensors. In this review, we discussed the multiple roles of DNA sensing in the pathological process of ischemic stroke, with a special focus on DNA sensors Toll-like receptor 9 (TLR9), absent in melanoma 2 (AIM2) and cyclic GMP-AMP synthase (cGAS).
25 Dec 2022Submitted to European Journal of Neuroscience
25 Dec 2022Submission Checks Completed
25 Dec 2022Assigned to Editor
03 Jan 2023Review(s) Completed, Editorial Evaluation Pending
11 Jan 2023Reviewer(s) Assigned
11 Mar 2023Editorial Decision: Accept