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Lethal toxicity of anticancer drugs in Xeroderma pigmentosum
  • +2
  • Debabrata Mohapatra,
  • Rachna Seth,
  • Aanchal Kakkar,
  • Jagdish Meena,
  • Aditya Gupta
Debabrata Mohapatra
All India Institute of Medical Sciences Department of Pediatrics
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Rachna Seth
All India Institute of Medical Sciences Department of Pediatrics

Corresponding Author:drrachnaseth1967@gmail.com

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Aanchal Kakkar
All India Institute of Medical Sciences Department of Pathology
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Jagdish Meena
All India Institute of Medical Sciences Department of Pediatrics
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Aditya Gupta
All India Institute of Medical Sciences Department of Pediatrics
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Abstract

Xeroderma pigmentosum (XP) is a rare genodermatosis characterized by defective DNA repair, leading to hypersensitivity to ultraviolet (UV) sunlight and predisposes to various cutaneous and non-cutaneous malignancies. Platinum compounds are used against cutaneous cancers as concurrent chemoradiotherapy. But the XP gene polymorphism has a potential role in metabolism of these agents and their susceptibility. Here, we report a case of cutaneous squamous cell carcinoma in a patient with XP who had severe toxicity to chemotherapy. We also discuss other similar cases reported in literature of this entity, to highlight this potentially lethal pharmacogenomic association.
27 Dec 2022Submitted to Pediatric Blood & Cancer
27 Dec 2022Submission Checks Completed
27 Dec 2022Assigned to Editor
27 Dec 2022Review(s) Completed, Editorial Evaluation Pending
27 Dec 2022Editorial Decision: Revise Minor
06 Jan 20231st Revision Received
06 Jan 2023Submission Checks Completed
06 Jan 2023Assigned to Editor
06 Jan 2023Review(s) Completed, Editorial Evaluation Pending
07 Jan 2023Editorial Decision: Accept