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KIR2DL4/HLA-G polymorphisms were associated with HCV infection susceptibility among Chinese high-risk population
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  • Ming Yue,
  • Zepei Feng,
  • Peng Huang,
  • Jinwei Zhang,
  • Xueshan Xia,
  • A-Mei Zhang,
  • Tian Zeng,
  • Qiong Chen,
  • Chuanlong Zhu,
  • Wei-long Tan,
  • Yun Zhang
Ming Yue
Affiliated Hospital of Nanjing Medical University

Corresponding Author:yueming@njmu.edu.cn

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Zepei Feng
Nanjing Medical University Department of Epidemiology
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Peng Huang
Nanjing Medical University Department of Epidemiology
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Jinwei Zhang
Affiliated Drum Tower Hospital of Medical College of Nanjing University
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Xueshan Xia
Kunming University of Science and Technology
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A-Mei Zhang
Kunming University of Science and Technology
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Tian Zeng
Affiliated Hospital of Nanjing Medical University
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Qiong Chen
Eastern Theater Command Centers for Disease Prevention and Control
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Chuanlong Zhu
Affiliated Hospital of Nanjing Medical University
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Wei-long Tan
Eastern Theater Command Centers for Disease Prevention and Control
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Yun Zhang
Nanjing Medical University Center for Global Health
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Abstract

Background: Killer-cell immunoglobulin-like receptors 2DL4 ( KIR2DL4) and the human leukocyte antigen class I-G ( HLA-G) display vital parts in immune responses against HCV infection. We select four potentially functional SNPs of KIR/HLA to explore the associations between KIR2DL4/HLA-G genetic variants and HCV infection results. Methods: In the present case-control investigation, KIR2DL4-rs660773, KIR2DL4-rs660437, HLA-G-rs9380142, and HLA-G-rs1707 SNPs were sorted as genotype in a total of 2225 high-risk subjects, involving 1778 paid blood donors and 447 drug users. The SNPs were functionally annotated using bioinformatics analysis. Results: Following adjusting by age, sex, ALT, AST, IFNL4-rs12979860, IFNL4-rs8099917, and the infection route, the logistic regression analysis (LRA) discovered that KIR2DL4-rs660773 and HLA-G-rs9380142 were correlated with vulnerability to HCV infection (all P <0.05). In a locus-dosage way, compared with subjects carrying the rs9380142-AA or rs660773-AA genotypes, subjects with rs9380142-AG or rs660773-AG/GG (all P <0.05) were more vulnerable to HCV infection; the overall impact of their risk genotypes (rs9380142-AGrs660773-AG/GG) was correlated with an elevated incidence of HCV infection ( Ptrend<0.001). In the Haplotype analysis, patients with haplotype AG were more likely to contract HCV compared to those with the highest common AA haplotype ( P= 0.002) were higher in susceptibility to infect HCV.nThe SNPinfo web server estimated that rs660773 is a transcription factor binding site (TFBS), whereas rs9380142 is a potential microRNA-binding site. Conclusion: In the Chinese high-risk population, KIR2DL4 rs660773 and HLA-G rs9380142 polymorphisms are related to HCV susceptibility .
12 Dec 2022Submitted to Journal of Medical Virology
20 Dec 2022Submission Checks Completed
20 Dec 2022Assigned to Editor
20 Dec 2022Review(s) Completed, Editorial Evaluation Pending
21 Dec 2022Reviewer(s) Assigned
11 Jan 2023Editorial Decision: Revise Minor
23 Feb 20231st Revision Received
03 Mar 2023Submission Checks Completed
03 Mar 2023Assigned to Editor
03 Mar 2023Review(s) Completed, Editorial Evaluation Pending
06 Mar 2023Editorial Decision: Accept