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Colchicine enhances β-adrenoceptor-mediated vasodilation in men with essential hypertension
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  • Thomas Svare Ehlers,
  • Jennifer van der Horst,
  • Sophie Møller,
  • Peter Piil,
  • Lasse Gliemann,
  • Christian Aalkjær,
  • Thomas Qvistgaard Jepps,
  • Ylva Hellsten
Thomas Svare Ehlers
University of Copenhagen Faculty of Science

Corresponding Author:thomas.ehlers@gmail.com

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Jennifer van der Horst
University of Copenhagen Faculty of Science
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Sophie Møller
University of Copenhagen Faculty of Science
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Peter Piil
University of Copenhagen Faculty of Science
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Lasse Gliemann
University of Copenhagen Faculty of Science
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Christian Aalkjær
Aarhus Universitet
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Thomas Qvistgaard Jepps
University of Copenhagen Faculty of Health and Medical Sciences
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Ylva Hellsten
University of Copenhagen Faculty of Science
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Abstract

Aims: Colchicine treatment has known beneficial effects on cardiovascular health and reduces the incidence of cardiovascular disease. Studies in isolated rodent arteries have shown that colchicine can enhance β-adrenoceptor-mediated vasodilation. In this translational study we examined whether this effect of colchicine was present in humans by conducting a double-blinded, placebo controlled intervention study. Methods and Results : Middle-aged men with essential hypertension were randomly assigned firstly to acute treatment with either 0.5 mg colchicine or placebo, and subsequently re-randomized for 3 weeks of treatment with either colchicine 0.5 mg twice daily (n=16) or placebo (n=15) followed by a washout period of 48-72 h. The vasodilator responses to isoprenaline, acetylcholine and sodium nitroprusside, were determined as well as arterial pressure, arterial compliance and plasma inflammatory markers. Acute colchicine treatment increased isoprenaline- (by 38% for the highest dose) as well as SNP- (by 29% main effect) induced vasodilation, but had no effect on the response to acetylcholine. Conclusion: Three weeks of twice daily treatment of colchicine, followed by a wash-out period, did not induce an accumulated or sustained effect on the β-adrenoceptor response and there was no effect on either arterial pressure, arterial compliance or on the level of measured inflammatory markers. The results provide novel translational evidence for a transient enhancing effect of colchicine on β-adrenoceptor-mediated vasodilation in humans with essential hypertension
21 Sep 2022Submitted to British Journal of Clinical Pharmacology
22 Sep 2022Submission Checks Completed
22 Sep 2022Assigned to Editor
23 Sep 2022Reviewer(s) Assigned
12 Nov 2022Review(s) Completed, Editorial Evaluation Pending
20 Nov 2022Editorial Decision: Revise Major
20 Dec 20221st Revision Received
21 Dec 2022Submission Checks Completed
21 Dec 2022Assigned to Editor
21 Dec 2022Review(s) Completed, Editorial Evaluation Pending
21 Dec 2022Reviewer(s) Assigned
05 Jan 2023Editorial Decision: Accept