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Impact on right ventricular performance in patients undergoing permanent pacemaker implantation: left bundle branch pacing versus right ventricular septum pacing
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  • Xinyi Huang,
  • Manxin Lin,
  • Shu-fen Huang,
  • Jincun Guo,
  • Linlin Li,
  • Simei Chen,
  • Kunhui Huang,
  • Jian Wu,
  • Maolong Su,
  • Binni Cai
Xinyi Huang
Xiamen University

Corresponding Author:hxysally1024@163.com

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Manxin Lin
Xiamen University
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Shu-fen Huang
Xiamen University
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Jincun Guo
Xiamen University
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Linlin Li
Xiamen University
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Simei Chen
Xiamen University
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Kunhui Huang
Xiamen University
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Jian Wu
Xiamen University
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Maolong Su
Xiamen University
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Binni Cai
Xiamen University
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Abstract

Background: The novel method of left bundle branch pacing (LBBP) has been reported to achieve better electrical and mechanical synchrony in the left ventricle than conventional right ventricular pacing (RVP). However, its effects on right ventricle (RV) performance are still unknown. Methods: Consecutive patients undergoing dual-chamber pacemaker (PM) implantation for sick sinus syndrome (SSS) with normal cardiac function and a narrow QRS complex were recruited for the study. The pacing characteristics and echocardiogram parameters were measured to evaluate RV function, interventricular and RV synchrony, and were compared among ventricular pacing‐on and native‐conduction modes. Results: A total of 84 patients diagnosed with SSS and an indication for pacing therapy were enrolled. Forty-two patients (50%; mean age 65.50 ± 9.30 years; 35% male) underwent successful LBBP and 42 patients (50%; mean age 69.26 ± 10.08 years; 33% male) RVSP, respectively. Baseline characteristics were similar between the two groups. We found no significant differences in RV function [RV-FAC (Fractional Area Change)%, 47.13±5.69 vs. 48.60±5.83, p=.069; Endo-GLS (Global Longitudinal Strain)%, -28.88±4.94 vs. -29.82±5.35, p=.114; Myo-GLS%, -25.72±4.75 vs. -25.72±5.21, p=.559; Free Wall St%, 27.40±8.03 vs. -28.71±7.34, p=.304] between the native‐conduction or LBBP capture modes, while the RVSP capture mode was associated with a significant reduction in the above parameters compared with the native‐conduction mode (P < .0001). The interventricular synchrony in the LBBP group was also superior to the RVSP group significantly. Conclusion: LBBP is a pacing technique that seems to associate with a positive and protective impact on RV performance.
23 May 2022Submitted to Journal of Cardiovascular Electrophysiology
23 May 2022Submission Checks Completed
23 May 2022Assigned to Editor
03 Jun 2022Reviewer(s) Assigned
01 Jul 2022Review(s) Completed, Editorial Evaluation Pending
04 Jul 2022Editorial Decision: Revise Minor
03 Aug 20221st Revision Received
04 Aug 2022Submission Checks Completed
04 Aug 2022Assigned to Editor
18 Aug 2022Reviewer(s) Assigned
03 Sep 2022Review(s) Completed, Editorial Evaluation Pending
08 Sep 2022Editorial Decision: Accept