In this study, the dissociation constants of the eight amines, namely, N-(2-aminoethyl)-1,3-propanediamine, 2-methylpentamethylene diamine, N, n-dimethyldipropylene-triamine, 3,3’-Diamino-n-methyldipropylamine, Bis[2-(n, n-dimethylamino) ethyl]ether, 2-[2-(Dimethylamino) ethoxy] Ethanol, 2-(dibutylamino) Ethanol and N-propylethanolamine were determined from 298.15 K to 313.15 K. Using the van’t Hoff equation, thermodynamic properties such as the standard state changes of enthalpy, entropy and Gibbs free energy were calculated. Using computational chemistry calculations, the amino group protonated first was predicted. Furthermore, computer free group contribution methods such as the original Perrin-Dempsey-Serjeant (PDS), the modified PDS and the Qian-Sun-Sun-Gao (QSSG) model were used to estimate the dissociation constants of the studied amines. In these methods, the QSSG provided the most accurate results as the database used in this method was updated with additional the functional groups as well as information about group positions. Finally, an artificial neural network was used to predict the pKa values.