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Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials
  • Nicholas White,
  • James Watson,
  • Kevin Baird
Nicholas White
Faculty of Tropical Medicine, Mahidol Iniversity

Corresponding Author:nickw@tropmedres.ac

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James Watson
Mahidol University Faculty of Tropical Medicine
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Kevin Baird
Eijkman Institute for Molecular Biology
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Abstract

Methaemoglobin results from the oxidation of ferrous to ferric iron in the centre of the haem moeity of haemoglobin. The production of dose-dependent methaemoglobinaemia by 8-aminoquinoline antimalarial drugs appears to be associated with, but is not directly linked to therapeutic efficacy against latent vivax and ovale malarias. Iatrogenic methaemoglobinaemia may be a useful pharmacodynamic measure in 8-aminoquinoline drug and dose optimization.

Peer review status:Published

22 Nov 2021Submitted to British Journal of Clinical Pharmacology
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24 Nov 2021Submission Checks Completed
24 Nov 2021Assigned to Editor
14 Dec 2021Reviewer(s) Assigned
17 Dec 2021Review(s) Completed, Editorial Evaluation Pending
17 Dec 2021Editorial Decision: Revise Minor
18 Dec 20211st Revision Received
20 Dec 2021Submission Checks Completed
20 Dec 2021Assigned to Editor
20 Dec 2021Review(s) Completed, Editorial Evaluation Pending
31 Dec 2021Editorial Decision: Accept
Jun 2022Published in British Journal of Clinical Pharmacology volume 88 issue 6 on pages 2657-2664. 10.1111/bcp.15219