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Targeting Mitochondrial Proteases for Therapy of Acute Myeloid Leukemia
  • +1
  • Xinrong Xiang,
  • Rui Bao,
  • Yu Wu,
  • Youfu Luo
Xinrong Xiang
Sichuan University West China Hospital
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Rui Bao
Sichuan University West China Hospital
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Yu Wu
Sichuan University West China Hospital
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Youfu Luo
Sichuan University West China Hospital
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Abstract

Targeting cancer metabolism has emerged as an attractive approach to improve therapeutic regimens in acute myeloid leukemia (AML). Mitochondrial proteases are closely related to cancer metabolism, but their biological functions have not been well characterized in AML. According to different catogory, we comprehensively reviewed the role of mitochondrial proteases in AML. This review highlights some ‘powerful’ mitochondrial protease targets, including their biological function, chemical modulators, and applicative prospect in AML.

Peer review status:UNDER REVIEW

25 Nov 2021Submitted to British Journal of Pharmacology
26 Nov 2021Assigned to Editor
26 Nov 2021Submission Checks Completed
03 Dec 2021Reviewer(s) Assigned