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COVID-19 vaccine (mRNA BNT162b2) and COVID-19 Infection-Induced Thrombotic Thrombocytopenic Purpura in Adolescents
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  • Luna Vorster,
  • Susan Kirk,
  • Eyal Muscal,
  • Jenny Despotovic,
  • Clay Cohen,
  • Sarah Sartain
Luna Vorster
Baylor College of Medicine
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Susan Kirk
Baylor College of Medicine Department of Pediatrics
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Eyal Muscal
Baylor College of Medicine/Texas Children's Hospital
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Jenny Despotovic
Texas Children's Hospital
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Clay Cohen
Baylor College of Medicine
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Sarah Sartain
Baylor College of Medicine
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Abstract

The mRNA COVID-19 vaccine and COVID-19 infection caused by the SARS-CoV-2 virus may be immunologic triggers for the development of thrombotic thrombocytopenic purpura (TTP). There is not yet literature that discusses TTP induced by COVID-19 vaccination or infection in pediatric or adolescent patients. We describe 4 adolescents presenting with TTP (both de novo and relapsed disease) following administration of the Pfizer COVID-19 vaccine or after COVID-19 infection. Our observations demonstrate that the Pfizer-BioNTech mRNA vaccine and COVID-19 infection can act as triggers for the development/relapse of both congenital and acquired TTP.

Peer review status:UNDER REVIEW

23 Nov 2021Assigned to Editor
23 Nov 2021Submission Checks Completed
23 Nov 2021Submitted to Pediatric Blood & Cancer
24 Nov 2021Reviewer(s) Assigned