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Preparation and application of taste bud organoids in biomedicine towards chemical sensation mechanisms
  • +5
  • Shuge Liu,
  • Ping Zhu,
  • Yulan Tian,
  • Yating Chen,
  • Yage Liu,
  • Wei Chen,
  • Liping Du,
  • Chunsheng Wu
Shuge Liu
Xi'an Jiaotong University Institute of Medical Engineering

Corresponding Author:4120115012@xjtu.edu.cn

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Ping Zhu
Xi'an Jiaotong University
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Yulan Tian
Xi'an Jiaotong University
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Yating Chen
Xi'an Jiaotong University Institute of Medical Engineering
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Yage Liu
Xi'an Jiaotong University Institute of Medical Engineering
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Wei Chen
Xi'an Jiaotong University Institute of Medical Engineering
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Liping Du
Xi'an Jiaotong University
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Chunsheng Wu
Xi'an Jiaotong University
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Abstract

Taste is one of the most basic and important sensations that is able to monitor the food quality and avoid intake of potential danger materials. Whether as an inevitable symptom of aging or a complication of cancer treatment, taste loss so seriously affects the patient’s life quality. Taste bud organoids provide a great convenience for the research of taste functions and the underlying mechanisms due to their characteristics of availability, strong maneuverability, and high similarity to the in-vivo taste buds. This review gives a systemic and comprehensive introduction to the preparation and application of taste bud organoids towards chemical sensing mechanisms. For the first, the basic structure and function of taste buds in biomedicine will be brief introduced. Then, the currently available approaches for the preparation of taste bud organoids are summarized and discussed, which are mainly divided into two categories, i.e. stem/progenitor cell-derived approach and tissue-derived approach. For the next, different applications of taste bud organoids in biomedicine are outlined based on their central roles such as disease modeling, biological sensing, gene regulation, and signal transduction. Finally, the current challenges, future development trends and prospects of research in taste bud organoids are proposed and discussed.
08 Sep 2021Submitted to Biotechnology and Bioengineering
08 Sep 2021Submission Checks Completed
08 Sep 2021Assigned to Editor
06 Nov 2021Reviewer(s) Assigned
05 Jan 2022Review(s) Completed, Editorial Evaluation Pending
05 Jan 2022Editorial Decision: Revise Major
11 Feb 20221st Revision Received
11 Feb 2022Submission Checks Completed
11 Feb 2022Assigned to Editor
13 Apr 2022Review(s) Completed, Editorial Evaluation Pending
13 Apr 2022Editorial Decision: Accept