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Nano-Bio-Engineered Silk Matrix based Sensing Devices for Molecular Bioanalysis
  • +2
  • Aditi Sammi,
  • Divya .,
  • Supratim Mahapatra,
  • Rahul Kumar,
  • Pranjal Chandra
Aditi Sammi
Indian Institute of Technology BHU Varanasi

Corresponding Author:aditi.sammi.bce19@iitbhu.ac.in

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Divya .
Indian Institute of Technology BHU Varanasi
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Supratim Mahapatra
Indian Institute of Technology BHU Varanasi
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Rahul Kumar
Indian Institute of Technology BHU Varanasi
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Pranjal Chandra
Indian Institute of Technology BHU Varanasi
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Abstract

Silk is a fibrous protein, has been a part of human lives for centuries and was used as suture and textile material. Silk is mainly produced by members of certain arthropods such as spiders, butterflies, mites, and moths. However, recent biotechnological advances have revolutionized silk as a biomaterial for various applications ranging from diverse sensors to robust fibers. The biocompatibility, mechanical resilience, and biodegradability of the material make it a suitable candidate for biomaterials. Silk can also be easily converted into several morphological forms, including fibers, films, sponges, and hydrogels. Provided these abilities, silk has received excellent traction from scientists worldwide for various developments, one of them being its use as a bio-sensor. The diversity of silk materials offers various options, giving scientists the freedom to choose from and personalize them as per their needs. In this review, we foremost look upon the composition, production, properties, and various morphologies of silk. The numerous applications of silk and its derivatives for fabricating biosensors to detect small molecules, macromolecules, and cells have been explored comprehensively. Also, the data from various globally developed sensors using silk have been described into organized tables for each category of molecules, along with their important analytical details.
15 Oct 2021Submitted to Biotechnology and Bioengineering
16 Oct 2021Submission Checks Completed
16 Oct 2021Assigned to Editor
28 Oct 2021Reviewer(s) Assigned
28 Nov 2021Review(s) Completed, Editorial Evaluation Pending
28 Nov 2021Editorial Decision: Revise Minor
03 Dec 20211st Revision Received
06 Dec 2021Submission Checks Completed
06 Dec 2021Assigned to Editor
08 Dec 2021Reviewer(s) Assigned
22 Dec 2021Review(s) Completed, Editorial Evaluation Pending
22 Dec 2021Editorial Decision: Accept