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The correlation of blood pressure variability and cognitive function in hypertension patients: a meta-analysis
  • Xiaojie Jin,
  • Yi Lu,
  • Peng Zhao
Xiaojie Jin
Tianjin First Central Hospital

Corresponding Author:zgo48012928@163.com

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Yi Lu
Tianjin First Central Hospital
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Peng Zhao
Tianjin First Central Hospital
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Abstract

Background: Cognitive impairment is very common in patients with hypertension, it’s necessary to conduct a meta-analysis to evaluate the association of cognitive function and blood pressure variability in patients with hypertension, to provide insights into the clinical management of hypertension and cognitive impairment. Methods: We searched PubMed et al databases for the case-control studies on the association between blood pressure variability and cognitive function up to July 15, 2021. Two researchers independently screened the literature and retrieved the data. RevMan 5.3 was used for data meta-analysis Results: A total of 13 studies involving 2754 patients were included. Meta-analysis indicated that 24-hour systolic [MD= 3.54, 95% CI (2.48, 4.60)] and diastolic [MD=2.43, 95%CI (1.55, 3.31)] blood pressure variation coefficient in the CI group were significantly higher than that of no CI group (all P<0.05). Standard deviation of systolic [MD=2.20, 95% CI (0.27, 4.13)] and diastolic [MD=1.79, 95% CI (0.80, 2.79)] blood pressure variation in the CI group were significantly higher than that of no CI group (all P<0.05). Mean systolic [MD=3.73, 95% CI (0.92, 6.53)]and diastolic [MD = 5.41, 95% CI (0.42, 10.40)] blood pressure variation in the CI group were significantly higher than that of no CI group (all P<0.05). There were no statistically significant differences in the morning peak systolic [MD=7.85,95% CI (-1.30,17.01)] and diastolic [MD=4.44,95% CI (-6.00, 14.89)] blood pressure drop between the CI group and no CI group(all P>0.05). Conclusion: Cognitive impairment in hypertensive patients is closely associated with increased blood pressure variability, and clinical medical staff should pay attention to the management of blood pressure variability in hypertensive patients to reduce the development of cognitive impairments.
19 Aug 2021Submitted to International Journal of Clinical Practice
20 Aug 2021Submission Checks Completed
20 Aug 2021Assigned to Editor
06 Sep 2021Reviewer(s) Assigned
07 Sep 2021Review(s) Completed, Editorial Evaluation Pending
08 Sep 2021Editorial Decision: Revise Minor
14 Sep 20211st Revision Received
15 Sep 2021Submission Checks Completed
15 Sep 2021Assigned to Editor
15 Sep 2021Review(s) Completed, Editorial Evaluation Pending
15 Sep 2021Editorial Decision: Accept
11 Oct 2021Published in International Journal of Clinical Practice. 10.1111/ijcp.14885