loading page

Effects of general anesthesia and ultrasonography-guided interscalene block on pain and oxidative stress in shoulder arthroscopy: a randomized trial
  • +5
  • MURAT ÖKSÜZ,
  • Suheyla Abitagaoglu,
  • Ahmet Kaciroglu,
  • Ceren Koksal,
  • Burak Yagmur Ozturk,
  • Özcan Erel,
  • Almila Senat Aydin,
  • Dilek Erdogan Ari
MURAT ÖKSÜZ
Sancaktepe Şehit Prof Dr Ilhan Varank Training and Research Hospital

Corresponding Author:oksuzmurat@hotmail.com

Author Profile
Suheyla Abitagaoglu
Fatih Sultan Mehmet Training and Research Hospital
Author Profile
Ahmet Kaciroglu
Bursa City Hospital
Author Profile
Ceren Koksal
Fatih Sultan Mehmet Training and Research Hospital
Author Profile
Burak Yagmur Ozturk
Fatih Sultan Mehmet Training and Research Hospital
Author Profile
Özcan Erel
Ankara Yildirim Beyazit Universitesi Tip Fakultesi
Author Profile
Almila Senat Aydin
Ankara Yildirim Beyazit Universitesi Tip Fakultesi
Author Profile
Dilek Erdogan Ari
Fatih Sultan Mehmet Training and Research Hospital
Author Profile

Abstract

Background/aim: The aim of this study was to evaluate the effects of general anesthesia and ultrasonography-guided interscalene block on pain and oxidative stress evaluated by thiol–disulphide balance and C-reactive protein levels in patients undergoing shoulder arthroscopy. Materials and methods: A total of 42 patients aged 18–75 years who were scheduled to undergo shoulder arthroscopy were randomized into interscalene block group (Group-IB, n = 20) and general anesthesia group (Group-GA, n = 22). All patients received patient-controlled analgesia during the postoperative period. Additional analgesics were administered to patients with a visual analog scale score of > 4. Native -thiol, total -thiol, disulphide and C-reactive protein levels were measured. Patients’ visual analog scale scores, morphine and additional analgesic consumption were recorded. A shift in thiol–disulphide balance toward decreased thiol and increased disulphide levels was regarded as an indicator of oxidative stress. Results: Pain level, morphine and additional analgesic consumption were higher in Group-GA. Native-thiol and total-thiol levels were higher in Group-IB postoperatively and also disulphide levels were lower at postoperative 18 hours. C-reactive protein levels were similar in both the groups. Conclusion: Interscalene block induced less oxidative stress during the postoperative period, as evaluated by thiol–disulphide balance.
05 Jun 2021Submitted to International Journal of Clinical Practice
05 Jun 2021Submission Checks Completed
05 Jun 2021Assigned to Editor
15 Jun 2021Reviewer(s) Assigned
22 Jun 2021Review(s) Completed, Editorial Evaluation Pending
24 Jun 2021Editorial Decision: Revise Major
28 Sep 20211st Revision Received
28 Sep 2021Submission Checks Completed
28 Sep 2021Assigned to Editor
28 Sep 2021Review(s) Completed, Editorial Evaluation Pending
04 Oct 2021Editorial Decision: Accept