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Pancreatoblastoma in children: EXPeRT/PARTNER diagnostic and therapeutic recommendations.
  • +17
  • Ewa Bien,
  • Jelena Roganovic,
  • MALGORZATA Krawczyk,
  • Jan Godziński,
  • Daniel Orbach,
  • Giovanni Cecchetto,
  • Winfred Barthlen,
  • Anne-Sophie Defachelles,
  • Andrea Ferrari,
  • Christopher Weldon,
  • Ines Brecht,
  • Dominik T. Schneider,
  • Gianni Bisogno,
  • Alexandra Kolenova,
  • Tal Ben-Ami,
  • Kata Martinova,
  • Calogero Virgone,
  • Teresa Stachowicz-Stencel,
  • Denis Kachanov,
  • Yves Reguerre
Ewa Bien
Medical University of Gdansk
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Jelena Roganovic
Clinical Hospital Center Rijeka, University of Rijeka
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MALGORZATA Krawczyk
Medical University of Gdansk
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Jan Godziński
Marciniak Hospital
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Daniel Orbach
Institut Curie
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Giovanni Cecchetto
University of Padua
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Winfred Barthlen
Universitatsmedizin Greifswald
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Anne-Sophie Defachelles
Centre Oscar Lambret
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Andrea Ferrari
Istituto Nazionale Tumori, Milano
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Christopher Weldon
Boston Children's Hospital, Dana-Farber Cancer Institute, & Harvard University
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Ines Brecht
University of Tübingen
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Dominik T. Schneider
Klinikum Dortmund
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Gianni Bisogno
Division of Hematology/Oncology
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Alexandra Kolenova
Comenius University - Medical School and University Children’s Hospital
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Tal Ben-Ami
Kaplan Medical Center
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Kata Martinova
University Clinical Centre Mother Teresa Skopje
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Calogero Virgone
University of Padua
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Teresa Stachowicz-Stencel
Medical University of Gdansk
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Denis Kachanov
National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Samory Mashela str. 1, 117997
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Yves Reguerre
Felix Guyon Hospital, St Denis, La Réunion
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Abstract

Pancreatoblastoma (PBL) is a rare malignant epithelial neoplasm affecting typically young children. Signs related to advanced upper-abdominal tumor accompanied by elevated serum α-fetoprotein levels in a young child suggest PBL, however histopathological examination is required for diagnosis. The mainstay of treatment is a complete surgical resection. Inoperable and/or metastatic PBL may become amenable to complete, delayed surgery after neo-adjuvant chemotherapy. This manuscript presents the internationally consensus recommendations for the diagnosis and treatment of children with PBL, established by the European Cooperative Study Group for Pediatric Rare Tumors (EXPeRT) within the EU-funded PARTNER (Paediatric Rare Tumors Network – European Registry) project.

Peer review status:UNDER REVIEW

20 Feb 2021Submitted to Pediatric Blood & Cancer
20 Feb 2021Assigned to Editor
20 Feb 2021Submission Checks Completed
23 Feb 2021Reviewer(s) Assigned
23 Feb 2021Review(s) Completed, Editorial Evaluation Pending