Abstract
Background: An outbreak of severe acute respiratory syndrome corona
virus 2 (SARS-CoV-2 known as COVID-19) has led to more than 10,000
confirmed cases as of April 3rd 2020. Understanding the early spread
dynamics of the infection and evaluating the effectiveness of control
measures is crucial for assessing the potential for sustained
transmission to occur in new areas. Combining a mathematical model of
severe COVID-19 spread with four datasets from within and outside Wuhan,
China; we estimated how to spread in Wuhan varied between January and
February 2020. We used these estimates to assess the potential for
sustained human-to-human spread to occur in locations outside Wuhan if
diseases holders were introduced. Methodology: We united SEIR frame work
model with data on cases of COVID-19 in China and International cases
that originated in Wuhan to estimate how spread had varied over time
during January and February 2020. Based on these estimates, we
calculated the probability that freshly introduced cases might produce
outbreaks in other regions. Results: We calculated approximately the
median day by day basic reproduction number ( ) in Wuhan, refused from
2•45 (95% CI: 1•16–4•87) 1 week before travel restrictions were
introduced on Jan 23rd, 2020, to 1.05 (0•42–2•40) one week after. Based
on our estimates of , presumptuous SARS approximating disparity, we
computed that in locations with similar spread potential to Wuhan in
near the beginning January, some time ago there are at least four
independently set up cases, there is a more than fifty percent chance
the infection will found within that inhabitants. Conclusions: COVID-19
spreading probably refused in Wuhan during delayed January, 2020,
corresponding with the prologue of voyage control channels. As more
cases arrive in international locations with similar spread potential to
Wuhan before these organize measures, it is likely many chains of spread
will fail to create initially, but might lead to innovative outbreaks
ultimately.