A novel system of Monitoring Vibrations and Perturbations in the Lithosphere, Atmosphere, and Ionosphere (MVP-LAI) was established in Leshan, Sichuan, China in 2021. The system comprises 14 distinct instruments with 22 devices continuously monitoring changes in 14 geophysical parameters ranged between a few meter underground to ~350 km in altitude to examine and/or expose causal mechanisms of the LAI couplings. Note that the ground-based GNSS receivers of the system receive the electromagnetic signals from the geostationary BeiDou satellites that retrieve the total electron content over certain locations 24 × 7 without montage. Significant amplifications of TEC perturbations appear during the night since mid-May 2021. The M6.4 Yunnan and M7.4 Qinghai earthquakes occurred in Mainland China on 21-22 May 2021. The amplifications are related with the two earthquakes due to that the associated TEC perturbations reside over the epicenters. The resident TEC perturbations and ground vibrations close to the epicenters share a frequency of ~0.005 Hz, which can be attributed to the resonant coupling between the lithosphere and ionosphere.