The microstructures, textures and seismic anisotropy of a foliated blueschist-eclogite rock from Naga Hills Ophiolite (NHO) complex, North-East India has been investigated to understand the fabric relationship and deformation mechanism prevailed during the metamorphism and subduction of the Neo-Tethys oceanic crust. The Naga Hills blueschist-eclogite rock essentially contains omphacite, phengite, glaucophane, and garnet, representing an oceanic crust that experienced P-T stability field of blueschist and further eclogite metamorphism before it resurfaced accreting in the Naga Hills. Omphacite and glaucophane show weak shape preferred orientation (SPO), while phengite displays a strong SPO. The Crystallographic Preferred Orientations (CPO) of omphacite is characterized by the [001]-axes gridles within the foliation, and the (010)-poles concentrated sub-perpendicular to the foliation. For glaucophanes, the [001] axis aligns parallel to lineation and the [100] axis and (110) pole plunge perpendicular to foliation. These CPOs correspond to SL-type fabrics, related to a deformation geometry within the plain strain field and they developed from plastic deformation through dislocation creep. The seismic anisotropies of the individual minerals, blueschist-eclogite domains and their contributions in the bulk rock anisotropy has been discussed. The calculated seismic anisotropies (AVP and AVS) of bulk rock are 12.8% and 8.1%, respectively. This strong seismic anisotropy is due to the presence of phengite and glaucophane and can contribute to the observed seismic anisotropy in the subduction zone. The average low P-wave velocity of whole rock from NHO compared to blueschist is probably due to the low P-wave velocity of phengite (avg VP: 6.2 kms-1). Therefore, the low seismic velocity in the upper layer and the strong seismic anisotropy of the subducting oceanic crust can be attributed to the presence of glaucophane and phengite.