The study aims to assess the local response of the regional climate model version 4.6 (RegCM4.6) to the coupling of ocean-atmosphere interaction in Central Africa. The ability of the model is evaluated over six years (first January 2001, to thirty-first December 2006) by conducting two different experiments with the Grell convective scheme. The experiments are carried out monthly with a spatial resolution of 40 km. The model was forced by ERA-Interim reanalyses and validated by GPCP (Global Precipitation Climatology Project) observational data, ERA 5 and ERA-Interim reanalyses. To evaluate the influence of the slab-ocean, we carried out two different experiments: The first experiment is designed to produce the climatology and force the surface limits of RegCM with the sea surface temperature. The second experiment is designed to couple RegCM with the slab-ocean, which provides mutual interaction between the ocean and the atmosphere. Using statistical tools, we evaluated the model’s ability to simulate precipitation, surface temperature and wind. Both experiments reasonably reproduce the main characteristics of the rainfall regime, temperature and wind. A comparative analysis of the different experiments reveals that the performances of the experiments are similar in Central Africa and in the different homogeneous sub-regions as far as rainfall is concerned, but there are subtle differences. Slab-ocean improvement varies from season to season and from the sub-region to sub-region. However, we note a significant improvement in temperature and rainfall over the Indian Ocean.