We present an interdisciplinary study of observations of pre-earthquake processes associated with major earthquakes based on integrating space and ground- data. Recent large magnitude earthquakes in Asia and Europe have emphasized the various observations of multiple types of pre-earthquake signals recorded either on the ground or from space. Four physical parameters were measured from ground and satellite and used in our simulation models: 1) Ground Radon variation; 2) Outgoing Long-Wavelength Radiation (OLR) obtained from NPOES, NASA/AQUA) on top of the atmosphere (TOA); 3) Atmospheric Chemical Potential (ACP) obtained from NASA assimilation models and; 4) electron density variations in the ionosphere via GPS Total Electron Content (GPS/TEC). For this analysis we selected six large earthquakes from the last decade with differing geographic and seismo-tectonics regions: (1) M9.3, Off the West Coast of Northern Sumatra, Dec 26, 2004; (2) M9.0 Great Tohoku Earthquake, Japan, March 11, 2011; (3) and (4) M7.8 and M7.3 Gorkha, Nepal, 2015; (5); M8.2 Tehuantepec, Mexico, September 8, 2017 and; (6) M7.1, Puebla central Mexico earthquakes, September 19, 2017. Our preliminary results indicate an enhancements of radon (about a week to ten days prior) coincident (with some delay) with an increase in the atmospheric chemical potential measured near the epicenter from both satellite and subsequently with an increase of outgoing infrared radiation (OLR) observed on the TOA from NOAA/NASA (a week in advance). Finally GPS/TEC data indicate an increase of electron concentration 1-4 days before the earthquakes. Although the radon variations and some of satellite OLR anomalies were observed far (>2000km) from the epicenter areas the anomalies were always inside the estimates of the Dobrovolsky-Bowman area of preparation. We examined the possible correlation between magnitude and the spatial size of earthquake preparation zone in the framework of the Lithosphere –Atmosphere -Ionosphere Coupling hypothesis. The reliable detection of pre-earthquake signals for both sea and land earthquakes was possible only by integrating satellite and ground observations. A detail summary of our approach to this study of pre-earthquake research has just been published as AGU/Wiley Geophysical Monograph Series No. 234.