The NASA InSight mission, landing in late November 2018, promises to revolutionize our understanding of Martian interior structure via analysis of seismic data returned by the SEIS instrument. The extent to which the mission’s potential is realized will depend on the number of detectable seismic events that occur during the period of operation. Here I estimate the rate of detectable events generated by volcano-tectonic activity on Mars based on extrapolation of Hawai’i’s seismic record. I use a catalog of 5603 earthquakes spanning 48 years [IRIS, 2018], with moment magnitudes MW ranging from 3.0 to 6.9, to derive the Gutenberg-Richter (G-R) frequency-magnitude relation for the Island of Hawai’i, expressed as log(N) = a – b MW, where N is the number of earthquakes with magnitudes greater than or equal to MW, and a and b are constants. By this analysis, one earthquake with MW 5.1 or greater can be expected every year at Hawai’i. Under the assumption that the mechanisms of seismicity associated with edifice building are similar at Hawai’i and Olympus Mons (supported by observation of decollement-based volcanic spreading at both), I use the same b for both settings and scale a according to estimates of magmatic volume flux rates dV/dt at both settings. Over the 80 Myr history of the Hawaiian-Emperor volcanic chain, dV/dt ≈ 1.7 x 10-2 km3/yr. An estimate of dV/dt for the Olympus Mons volcano on Mars was derived from paleotopographic analysis of a set of lava flows south of Olympus Mons with discordant topography. Given the mean flow age from crater counts (210 Ma), an estimate of the amount of volcanic material needed to cause deflections of flow orientations of the required magnitudes yields estimates of dV/dt over this timespan ranging from 6.33 x 10-4 to 6.43 x 10-3 km3/s. Taking the mean of these values and scaling a by the ratio of dV/dt values for Mars and Hawai’i yields a rate of at least 1 quake of MW = 4.4 or greater per year (Figure 1). Thus, under several assumptions (including a steady recent magma supply rate for Olympus Mons), we can expect ≈ 2 volcano-tectonically driven quakes of magnitude MW > 4.4 from the vicinity of Olympus Mons during the nominal 2 Earth-year InSight prime mission. This is a conservative lower bound that does not consider contributions from numerous potential volcano-tectonic sources in Tharsis and elsewhere on Mars.